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Allergy-Reduced Egg Project: Towards a Future Where Everyone Can Enjoy Eggs

Kewpie, Hiroshima University, Sagamihara Hospital Clinical Research Center and PtBio
Food & Agriculture
Sustainable procurement of food resources
  • Hen's egg allergy occurs when the body's immune system (specifically IgE antibodies) reacts to proteins present in eggs

  • In Japan, hen's egg allergy is the most prevalent food allergy

  • Among egg allergens, only ovomucoid (OVM) remains stable after heat treatment, making it a persistent challenge

  • While plant-based egg alternatives exist, they often fall short in replicating the authentic flavor and unique properties of eggs

  • This is why we're pioneering the development of OVM-free eggs, also known as allergy-reduced eggs

Understanding Hen's Egg Allergy

  • These are eggs produced by chickens that have had the ovomucoid gene selectively removed using PtBio's genome editing technology

  • Our research has confirmed that this genetic modification has no adverse effects on chicken growth and development

  • Through heat treatment, we can eliminate residual allergens while maintaining a taste and properties similar to conventional eggs

  • These eggs have potential applications in various egg-based food products, opening up new possibilities for those with egg allergies

  • We're currently validating the safety of processed foods using allergy-reduced eggs through rigorous serum tests and clinical trials with egg-allergic patients

What Are Allergy-Reduced Eggs?

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Allergy-Reduced Eggs vs. Conventional Eggs

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Our Project Implementation

This is a pioneering global initiative, shifting the paradigm from "avoiding eggs" to "consuming eggs safely".

  1. Breeding and developing chicken strains that produce allergy-reduced eggs

  2. Creating innovative processed foods using allergy-reduced eggs

  3. Conducting comprehensive safety trials for allergy-reduced eggs

  4. Implementing large-scale demonstration tests of production and processing facilities for allergy-reduced eggs

  5. Formulating strategic commercialization and branding plans

  • We're proud to announce that this project has been selected for the SBIR Phase 3: Ministry of Agriculture, Forestry and Fisheries of Japan's Small Business Innovation Research Promotion Project

Exciting Product Examples Using Allergy-Reduced Eggs

  • Our goal is to provide a wide range of egg-based food products that can be enjoyed by individuals with egg allergies and their families, catering to various occasions and preferences

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Egg for All: Our Vision

  • By introducing allergy-reduced eggs to society, we're contributing to the realization of "Egg for All" - a world where everyone can share a single dining table, regardless of allergy status

A Message to Our Stakeholders

  • PtBio is actively seeking partners who share our vision of creating an allergy barrier-free world. We warmly welcome collaboration opportunities with companies, research institutions, and healthcare professionals who resonate with our mission. Together, we can make a significant impact on the lives of millions affected by egg allergies.

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